上游原料
(2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoic acid[2-(chloromethoxy)ethyl](trimethyl)silanemethyl (2S)-2-pyrrolidinecarboxylate(2S)-2-[[(benzyloxy)carbonyl]amino]-3-(4-hydroxyphenyl)propionic acidN-BOC-L-threonine; Boc-Threonine; N-tert-Butoxycarbonyl-L-threonine; N-(tert-Butoxycarbonyl)-L-threonine; BOC-L-Threonine[2-(trimethylsilyl)ethoxy]methyl (2S,3R)-2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate(2S)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-(4-methoxyphenyl)propionic acid(2S,3R)-2-[(tert-butoxycarbonyl)amino]-3-[[(2S)-3-(4-methoxyphenyl)-2-(methylamino)propanoyl]oxy]butyric acid(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)-2-pyrrolidinecarboxylic acid(2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butyric acidN-benzyl-N-[2,6-dichloro-4-(1-pyrrolidinyl)-7-pteridinyl]amine; N-benzyl-2,6-dichloro-4-(1-pyrrolidinyl)-7-pteridinamine(2R,3S)-2-amino-3-methylpentanoic acid(2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butyric acid(2S)-2-(benzyloxy)-3-methylbutanaltert-butyl(dimethyl)silyl (E)-1-(tert-butylsulfanyl)-1-propenyl ether; tert-butyl[[(E)-1-(tert-butylsulfanyl)-1-propenyl]oxy]dimethylsilaneS-(tert-butyl) (2S,3S,4S)-4-(benzyloxy)-3-hydroxy-2,5-dimethylhexanethioate(2R,3S,4S)-4-(benzyloxy)-2,5-dimethyl-1,3-hexanediol(5S,6R)-5-[(1S)-1-(benzyloxy)-2-methylpropyl]-6,9,9,10,10-pentamethyl-2,4,8-trioxa-9-silaundecane; benzyl (1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl ether(3S,4S,5R)-6-[[tert-butyl(dimethyl)silyl]oxy]-4-(methoxymethoxy)-2,5-dimethyl-3-hexanol(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl acetatebenzyl (1R,2S)-1-(1H-imidazol-1-ylcarbonyl)-2-methylbutylcarbamate4-[[(benzyloxy)carbonyl]oxy]-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (4R,5S)-4-[[(benzyloxy)carbonyl]amino]-5-methyl-3-oxoheptanoate(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (3S,4R,5S)-4-[[(benzyloxy)carbonyl]amino]-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (3S,4R,5S)-4-amino-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (3S,4R,5S)-4-([(2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoyl]amino)-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate(1S,2S,3R)-4-[[tert-butyl(dimethyl)silyl]oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (3S,4R,5S)-4-([(2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoyl]amino)-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate(1S,2S,3R)-4-hydroxy-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (3S,4R,5S)-4-([(2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoyl]amino)-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate(3S,6R,7S,10R,11S,15S,16S,17S)-1-[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]-7-[(tert-butoxycarbonyl)amino]-15-isopropyl-3-(4-methoxybenzyl)-16-(methoxymethoxy)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13-tetraoxo-11-[(triisopropylsilyl)oxy]-5,14-dioxa-2,9-diazaoctadecan-18-oic acidtert-butyl (3S,6R,7S,10R,11S,15S,16S,17S,20S,25aS)-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-16-(methoxymethoxy)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,18,21-hexaoxo-11-[(triisopropylsilyl)oxy]docosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-ylcarbamatetert-butyl (3S,6R,7S,10R,11S,15S,16S,17S,20S,25aS)-16-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,18,21-hexaoxo-11-[(triisopropylsilyl)oxy]docosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-ylcarbamate(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-7-amino-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]tetradecahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosine-1,4,8,13,16,18,21(17H)-heptoneethyl (2S)-2-hydroxypropanoate; (S)-ethyl lactate2-(trimethylsilyl)-1-ethanolmethyl (2S)-2-pyrrolidinecarboxylate(2R)-2-[([(2S)-1-[(2S)-2-hydroxypropanoyl]pyrrolidinyl]carbonyl)(methyl)amino]-4-methylpentanoic acidethyl (2S)-2-[[tert-butyl(dimethyl)silyl]oxy]propanoateethyl (2S)-2-[[tert-butyl(dimethyl)silyl]oxy]propanoatemethyl (2S)-1-((2S)-2-[[tert-butyl(dimethyl)silyl]oxy]propanoyl)-2-pyrrolidinecarboxylate(2S)-1-((2S)-2-[[tert-butyl(dimethyl)silyl]oxy]propanoyl)-2-pyrrolidinecarboxylic acid(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoic acid2-(trimethylsilyl)ethyl (2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoate2-(trimethylsilyl)ethyl (2R)-4-methyl-2-(methylamino)pentanoate(2R)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid(2S)-2-[[(benzyloxy)carbonyl]amino]-3-(4-hydroxyphenyl)propionic acid(2-ethoxy-2-oxoethyl)lithium(2S)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-(4-methoxyphenyl)propionic acid(2R,3S)-2-[(tert-butoxycarbonyl)amino]-3-methylpentanoic acidethyl (4R,5S)-4-[(tert-butoxycarbonyl)amino]-5-methyl-3-oxoheptanoatetert-butyl (1R,2S)-1-formyl-2-methylbutylcarbamateethyl (3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-methylheptanoate2,2,2-trichloro-1-ethanol2,2,2-trichloroethyl (3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-methylheptanoate2,2,2-trichloroethyl (3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoate(2S,3R)-3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]butyric acid2,2,2-trichloroethyl (3S,4R,5S)-4-[[(2S,3R)-2-amino-3-(benzyloxy)butanoyl]amino]-3-hydroxy-5-methylheptanoate2,2,2-trichloroethyl (6R,9S,12R,13S)-13-[[tert-butyl(dimethyl)silyl]oxy]-9-[(1R)-1-hydroxyethyl]-6-isobutyl-2,2,5-trimethyl-12-[(1S)-1-methylpropyl]-4,7,10-trioxo-3-oxa-5,8,11-triazapentadecan-15-oate2,2,2-trichloroethyl (5S,8R,9S,12R,13S)-13-[[tert-butyl(dimethyl)silyl]oxy]-5-(4-methoxybenzyl)-4,8-dimethyl-9-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-12-[(1S)-1-methylpropyl]-3,6,10-trioxo-1-phenyl-2,7-dioxa-4,11-diazapentadecan-15-oate(5S,8R,9S,12R,13S)-13-[[tert-butyl(dimethyl)silyl]oxy]-5-(4-methoxybenzyl)-4,8-dimethyl-9-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-12-[(1S)-1-methylpropyl]-3,6,10-trioxo-1-phenyl-2,7-dioxa-4,11-diazapentadecan-15-oic acid2,2,2-trichloroethyl (6R,9S,12R,13S)-9-[(1R)-1-(benzyloxy)ethyl]-13-[[tert-butyl(dimethyl)silyl]oxy]-6-isobutyl-2,2,5-trimethyl-12-[(1S)-1-methylpropyl]-4,7,10-trioxo-3-oxa-5,8,11-triazapentadecan-15-oate(2R)-2-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentanoic acid8-chloro-11-(1-piperazinyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridineBenzyl alcohol; Phenylmethanolbenzyl (2S)-2-pyrrolidinecarboxylate(2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid；N-Boc-L-leucine(2S)-2-hydroxy-3-methylbutyric acid(5S,8R,9S,12R,13S)-13-[[tert-butyl(dimethyl)silyl]oxy]-5-(4-methoxybenzyl)-4,8-dimethyl-9-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-12-[(1S)-1-methylpropyl]-3,6,10-trioxo-1-phenyl-2,7-dioxa-4,11-diazapentadecan-15-oic acid5-((2S)-2-[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-3-methylbutylidene)-2,2-dimethyl-1,3-dioxane-4,6-dionebenzyl (4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-5-methyl-3-oxohexanoate(2S,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-2,5-dimethyl-3-oxohexanoic acidbenzyl (2S)-1-[(2S)-2-amino-4-methylpentanoyl]-2-pyrrolidinecarboxylatebenzyl (2S)-1-((2S)-2-[[(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl]amino]-4-methylpentanoyl)-2-pyrrolidinecarboxylatebenzyl (2S)-1-[(2S,5S,7S,11S,12R,15S,16R,19S)-11-[[tert-butyl(dimethyl)silyl]oxy]-2-isobutyl-7-isopropyl-19-(4-methoxybenzyl)-5,16,20-trimethyl-15-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-12-[(1S)-1-methylpropyl]-4,6,9,14,18,21-hexaoxo-23-phenyl-8,17,22-trioxa-3,13,20-triazatricos-1-anoyl]-2-pyrrolidinecarboxylate(2R)-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-[[tert-butyl(dimethyl)silyl]oxy]-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-4-methyl-2-(methylamino)pentanamide(2R)-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-4-methyl-2-(methylamino)pentanamideethyl (2S)-2-hydroxypropanoate; (S)-ethyl lactatemethyl (2S)-2-pyrrolidinecarboxylate(2R)-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-4-methyl-2-(methylamino)pentanamide(2S)-2-(benzyloxy)propionic acid(2S)-1-[(2S)-2-(benzyloxy)propanoyl]-2-pyrrolidinecarboxylic acid(2S)-1-(tert-butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic acid; N-alpha-t-BOC-L-proline; (2S)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoic acid(2S,4S)-4-(benzyloxy)-2,5-dimethyl-3-oxohexanoic acid2-(trimethylsilyl)ethyl (2S)-2-amino-4-methylpentanoate2-(trimethylsilyl)ethyl (2S)-2-[[(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl]amino]-4-methylpentanoate(3S,4R,5S)-4-[(tert-butoxycarbonyl)amino]-3-[[tert-butyl(dimethyl)silyl]oxy]-5-methylheptanoic acid(6R,7S,11S,13S,16S)-7-[[tert-butyl(dimethyl)silyl]oxy]-16-isobutyl-11-isopropyl-2,2,13-trimethyl-6-[(1S)-1-methylpropyl]-4,9,12,14-tetraoxo-3,10-dioxa-5,15-diazaheptadecan-17-oic acid2-(trimethylsilyl)ethyl (2S,3R)-2-amino-3-hydroxybutanoate2-(trimethylsilyl)ethyl (2S,3R)-2-([(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoyl]amino)-3-hydroxybutanoate(2S)-2-[[[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propionic acid2-(trimethylsilyl)ethyl (2S,3R)-2-([(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoyl]amino)-3-[((2S)-3-(4-methoxyphenyl)-2-[methyl[(2S)pyrrolidinylcarbonyl]amino]propanoyl)oxy]butanoate 2-(trimethylsilyl)ethyl (2S,3R)-2-([(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-4-methylpentanoyl]amino)-3-[[(2S)-2-[[((2S)-1-[(2S,5S,7S,11S,12R)-11-[[tert-butyl(dimethyl)silyl]oxy]-2-isobutyl-7-isopropyl-5,16,16-trimethyl-12-[(1S)-1-methylpropyl]-4benzyl (1R)-1-[([(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosinmethyl (2S)-2-pyrrolidinecarboxylate(2R)-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-4-methyl-2-(methylamino)pentanamide(2S)-1-[(2S)-2-(benzyloxy)propanoyl]-2-pyrrolidinecarboxylic acidbenzyl (1R)-1-[([(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin(2S)-N-[(1R)-1-[([(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-10-[(1S)-1-methylpropyl]-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]amino)carbonyl]-3-methylbutyl]-1-[(2S)-2-(benzyloxy)propanoyl]-N-methyl-2-pyrrolidinecarboxamideethyl (2S)-2-(benzyloxy)propanoatemethyl (2S)-1-[(2S)-2-(benzyloxy)propanoyl]-2-pyrrolidinecarboxylate
