上游原料
1-N-Boc-3-piperodone; tert-butyl 3-oxo-1-piperidinecarboxylatetert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate2,2,2-trifluoroethanimidamidetert-butyl 2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate2,4-bis(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidineethyl 2-bromo-2,2-difluoroacetate; Ethylbromodifluoroacetate; 2-bromo-2,2-difluoroacetic acid ethyl ester; bromodifluoroacetic acid ethyl esterethyl acrylatediethyl 2,2-difluoropentanedioateethyl 4,4-difluoro-5-hydroxypentanoateethyl 4,4-difluoro-5-(((perfluorobutyl)sulfonyl)oxy)pentanoate(2S)-4-(tert-butoxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutyric acidtert-butyl (3S)-4-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoatetert-butyl (3S)-3-cyano-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoatetert-butyl (3S)-4-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoatetert-butyl (3S)-4-(5,5-difluoro-2-oxopiperidin-1-yl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate(3S)-4-(5,5-difluoro-2-oxopiperidin-1-yl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acidtert-butyl N-[(2S)-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-1-(5,5-difluoro-2-oxopiperidin-1-yl)-4-oxobutan-2-yl]carbamate