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佛司可林
纠错 分享
CAS号 66575-29-9
中文别名 福斯高林;毛喉萜;考福新;锦紫苏醇;腺苷酸环化酶激活剂;佛司可林, 98+%;佛司可林(标准品)
英文别名 BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE; FORSKOHLIN; FORSKOLIN; FORSKOLIN, COLEUS FORSKOHLII; COLEONOL; COLFORSIN; 7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE; 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
分子量 410.5
分子式 C22H34O7
EINECS编号 266-410-9
综合信息 查看供应
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佛司可林物理化学性质

外观：白色粉末
鉴定方法：Mass, NMR
分析方法：HPLC-DAD or/and HPLC-ELSD
熔点 282-232 °C
沸点 520℃
密度 1.23
闪点 172℃
储存条件 −20°C
溶解度 : DMSO: 5 mg/mL stable at least 6 months at room temperature
form : powder
color : off-whiteMerck : 13,2500

佛司可林产品用途

用于含量测定、鉴定、药理实验等

佛司可林提取来源

毛喉鞘蕊花 Coleus forskohlii。草本，直立或上升，高约40厘米。茎粗壮，具四棱及四槽，分枝，被长柔毛。在上部较密。叶卵圆形，顶端钝或急尖，基部骤楔形下延成柄，边缘具圆齿，近肉质，两面密被绒毛及柔毛；叶柄长6-15毫米，密被柔毛。轮伞花序由6-10花组成，多数排列成总状花序，总状花序长约2.3-10厘米；苞片卵圆形，长约8毫米，宽约7毫米，顶端尾状急尖，边缘具缘毛，外面被微柔毛，在开花时脱落；萼钟形，长约6毫米，喉部内面密被长柔毛，5齿，后齿大，心形，顶端短尖，余4齿近三角形，先端钻状渐尖，在果时常增大且下弯；花冠紫蓝色，长约1.2-1.5厘米，外面被稀疏的腺点，花冠管向下弯，向喉部逐渐增大宽至3.5毫米，冠檐二唇形，上唇4浅裂，裂片不相等，下唇延长，长圆形，舟状；雄蕊4，内藏或稍外露，花丝在中部以下合生成鞘状；花柱外伸。小坚果圆形，压扁。花期9月。

佛司可林药理药效

具有抗高血压、抗肿瘤转移和抗青光眼等药理活性。




 

上下游产品信息



 

佛司可林安全说明书(MSDS)

类别：有毒物品
毒性分级:中毒
急性毒性:口服- 大鼠  LD50 2550  毫克/ 公斤; 口服- 小鼠 LD50: 2300 毫克/公斤
可燃性危险特性:可燃, 火场排出辛辣刺激烟雾 
灭火剂:砂土, 二氧化碳, 泡沫, 雾状水

佛司可林储运特性

储运特性 库房通风低温干燥; 与强酸, 强碱, 食品分开储运

安全术语
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36/37 Wear suitable protective clothing and gloves.
穿戴适当的防护服和手套。
风险术语
R21 Harmful in contact with skin.
与皮肤接触有害。
上游原料
3-Hydroxy-2-methyl-2-cyclohexen-1-one3-Methoxy-2-methyl-2-cyclohexen-1-one3-Methoxy-2,6,6-trimethyl-2-cyclohexen-1-one2,4,4-Trimethyl-3-vinyl-2-cyclohexen-1-one2,4,4-Trimethyl-3-vinyl-2-cyclohexen-1-ol2-Butynoic acid2,4,4-trimethyl-3-vinyl-2-cyclohexen-1-yl 2-butynoate(8aS,8bS)-3,6,6,8b-Tetramethyl-4,6,7,8,8a,8b-hexahydro-2H-naphtho[1,8-bc]furan-2-one(1S,8aS)-8-(Hydroxymethyl)-4,4,7,8a-tetramethyl-1,2,3,4,6,8a-hexahydro-1-naphthalenol(1aR,7S,7aR,7bR)-7b-(Hydroxymethyl)-1a,4,4,7a-tetramethyl-1a,2,4,5,6,7,7a,7b-octahydronaphtho[1,2-b]oxiren-7-ol(1aR,5aS,8bR,10aR)-8,8,8b,10a-Tetramethyl-4-phenyl-5a,7,8,8b,10,10a-hexahydro-6H-oxireno[2',3':7,8]naphtho[1,8-de][1,3]dioxepine(1R,2R,4R,4aR,8S,8aR)-8-(Benzyloxy)-1-(hydroxymethyl)-2,5,5,8a-tetramethyldecahydro-1,4-naphthalenediol(1R,2R,4R,4aR,8S,8aR)-8-(Benzyloxy)-1-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,5,5,8a-tetramethyldecahydro-1,4-naphthalenediol(3R,4R,4aR,5S,8aR)-5-(Benzyloxy)-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-hydroxy-3,4a,8,8-tetramethyloctahydro-1(2H)-naphthalenone(3R,4R,4aR,5S,8aR)-4-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-4,5-dihydroxy-3,4a,8,8-tetramethyloctahydro-1(2H)-naphthalenone(3aR,4R,6aR,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyloctahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-one(3aR,6aR,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-6a,7,8,9,9a,9b-hexahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-one(3aR,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-6a,7,8,9,9a,9b-hexahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-oneisopropenyl methyl ether; 2-methoxy-1-propene(3aR,6R,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-3a,6,6a,7,8,9,9a,9b-octahydronaphtho[1,8-de][1,3]dioxin-6-ol(3aR,6R,6aS,9aS,9bR)-3a-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-3a,6,6a,7,8,9,9a,9b-octahydronaphtho[1,8-de][1,3]dioxin-6-yl N,N-dimethylcarbamate(3aS,6aS,7S,7aR,8aR,8bR,8cR)-8b-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,2,6,6,8a,8c-hexamethyldecahydrooxireno[2',3':2,3]naphtho[1,8-de][1,3]dioxin-7-yl dimethylcarbamate(3aR,4R,5S,6S,6aS,9aS,9bR)-3a-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4,5-dihydroxy-2,2,4,7,7,9b-hexamethyldecahydronaphtho[1,8-de][1,3]dioxin-6-yl dimethylcarbamate(3aR,4R,5S,6S,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyldecahydronaphtho[1,8-de][1,3]dioxine-4,5,6-triol(3aS,6aR,7R,7aS,10aS,10bS,10cR)-6a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-7-hydroxy-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,6aR,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-6a-(hydroxymethyl)-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-1,1,5,5,7,10c-hexamethyl-9-oxooctahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxine-6a(1H)-carbaldehyde1-Propynyllithium(3aS,6aR,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-6a-(1-hydroxy-2-butynyl)-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,6aS,7R,7aS,10aS,10bS,10cR)-6a-(2-Butynoyl)-7-hydroxy-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(4aS,7aS,7bR,10aS,10bS,13aS,13bR)-2,6,6,7b,10,10,13b-Heptamethyl-7a,8,9,10,10a,10b,13a,13b-octahydro-4H,7bH-[1,3]dioxolo[4',5':3,4]pyrano[3',2':1,2]naphtho[1,8-de][1,3]dioxine-4,12-dione(2R,4aS,7aS,7bR,10aS,10bS,13aS,13bR)-2,6,6,7b,10,10,13b-Heptamethyl-2-vinyldecahydro-4H,7bH-[1,3]dioxolo[4',5':3,4]pyrano[3',2':1,2]naphtho[1,8-de][1,3]dioxine-4,12-dione(2R,4aS,7aS,10aS,10bR,11S,12S,12aR)-11,12-Dihydroxy-2,6,6,10,10,10b,12a-heptamethyl-2-vinyldecahydro-4H,8H-pyrano[2',3':7,8]naphtho[1,8-de][1,3]dioxin-4-one(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,6,10,10b-Tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyldodecahydro-1H-benzo[f]chromen-1-one; Deacetylforskolin
下游产品
Colforsin daropate hydrochloride; Colforsin dapropate hydrochloride; Colforsin daproate hydrochloride; NKH-477; Adehl