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维生素A酸
CAS号 302-79-4
中文别名 3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸; 全反式维 A 酸; 视黄酸; 维 A 酸; 维他命 A 酸; 维A酸; 反式葡萄酸又名维甲酸; 全反式维A酸; 维甲酸视网膜酸; 维生素甲酸; 维他命A酸; 维甲酸; 全反式维生素A酸 维甲酸; 反式葡萄酸又名维甲酸/视黄酸; 視網酸; 維生素A酸; 全反式维甲酸/视黄酸
英文别名 13-CIS-RETINOIC ACID; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; 3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2E,4E,6E,8E-NONATETRAENOIC ACID; 3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2Z,4E,6E,8E-NONATETRANENOIC ACID; 9-TRANS-RETINOIC ACID; 9-TRANS-TRETINOIN; AKOS 92103; ALL-TRANS-RETINOIC ACID; ALL-TRANS-RETINOIE ACID; ALL-TRANS-VITAMIN A ACID; ISOTRETINOIN; (L)-ISOTRETINOIN; RETINOIC ACID; RETINOIC ACID, 13-CIS-; RETINOIC ACID, ALL TRANS; RETINOIC ACID ALL TRANS ISOMER; TRANS-RETINOIC ACID; TRANS VITAMIN A ACID; TRETINOIN
分子量 300.44
分子式 C20H28O2
EINECS编号 206-129-0
综合信息 查看供应
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维生素A酸物理化学性质

外观性状:黄色或淡橙色结晶性粉末,熔点179-184℃
熔点 :180-181 °C(lit.)
储存条件 :2-8°C
form :powder
color :yellow
水溶解性 :insoluble
Merck :14,8165
BRN :2057223

维生素A酸产品用途

【用途一】用于异常型痤疮、鱼鳞病和异常型银屑病
【用途二】用于异常型痤疮、鱼磷病和异常型银屑病。
【用途三】维生素A酸(ATRA) 是一种维生素A酸受体(RAR)和Retinoid X 受体(RXR)的配体,结合上RAR 和 RXR作为转导因子,调控正常细胞和肿瘤细胞的生长和分化。细胞色素P450 (CYPs) 催化ATRA的羟基化;维生素A酸引导胚胎干细胞(embryonic stem cells) 演变成神经元。

安全术语
S36/37Wear suitable protective clothing and gloves.
穿戴适当的防护服和手套。
S45In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
若发生事故或感不适,立即就医(可能的话,出示其标签)。
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。
S53 Avoid exposure - obtain special instructions before use.
避免接触,使用前须获得特别指示说明。
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
穿戴适当的防护服、手套和护目镜或面具。
风险术语
R22Harmful if swallowed.
吞食有害。
R38 Irritating to skin.
刺激皮肤。
R63Possible risk of harm to the unborn child.
可能有对胎儿造成伤害的危险。
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
吸入、皮肤接触及吞食有害。
上游原料
2,2,6-Trimethylcyclohexanone2,6,6-trimethylcyclohex-1-en-1-yl trifluoromethanesulfonate ethyl (E)-4-(diethoxyphosphoryl)-3-methyl-2-butenoate(2E,4E,6E,8E)-ethyl 3,7-dimethyl-9-(tributylstannyl)nona-2,4,6,8-tetraenoate(E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one tributyl((1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)buta-1,3-dien-1-yl)stannane(2E,4E)-5-iodo-3-methylpenta-2,4-dienoic acid(((2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-yl)sulfonyl)benzenediethyl 2-(1-bromopropan-2-ylidene)malonatediethyl 2-((5E,7E)-6-methyl-4-(phenylsulfonyl)-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-5,7-dien-2-ylidene)malonate2-((5E,7E)-6-methyl-4-(phenylsulfonyl)-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-5,7-dien-2-ylidene)malonic acid(E)-1,3,3-trimethyl-2-(3-((trifluoromethyl)sulfonyl)prop-1-en-1-yl)cyclohex-1-ene(E)-3-(tributylstannyl)but-2-en-1-ol(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadien-1-ol(2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal1,3,3-trimethyl-2-((1E,3E)-3-methylhexa-1,3-dien-5-yn-1-yl)cyclohex-1-ene(2E,4E,6E,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoatedimethyl 2-(1-methylethylidene)malonate(E)-dimethyl 2-(4-(dimethylamino)but-3-en-2-ylidene)malonate(E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-onedimethyl 2-((2E,4E,7E)-6-oxo-8-(2,6,6-trimethylcyclohex-1-en-1-yl)octa-2,4,7-trien-2-yl)malonatedimethyl 2-((2E,4E,6E,8Z)-6-methyl-8-(2,6,6-trimethylcyclohex-2-en-1-ylidene)octa-2,4,6-trien-2-yl)malonate(E)-5,5-dimethoxy-1-(2,6,6-trimethylcyclohex-1-en-1-yl)pent-1-en-3-one(E)-2-(5,5-dimethoxy-3-methylenepent-1-en-1-yl)-1,3,3-trimethylcyclohex-1-ene(E)-3-methylene-5-(2,6,6-trimethylcyclohex-1-en-1-yl)pent-4-enaldimethyl 2-(1-methylethylidene)malonate