上游原料
5-bromo-6-methylpyridin-2-ol2,2,2-trifluoroethyl trifluoromethanesulfonate5-bromo-6-methyl-1-(2 2 2-trifluoroethyl)pyridin-2(1H)-one(2 3 6-trifluorophenyl)boronic acid6-methyl-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)pyridin-2(1H)-one6-methyl-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-2-one2,4,6-triisopropylbenzenesulfonyl azide3-azido-6-methyl-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-2-onetert-butyl ((3S 5S 6R)-6-methyl-2-oxo-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-3-yl)carbamate(3S 5S 6R)-3-amino-6-methyl-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-2-one hydrochloride(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid2-(2 3 6-trifluorophenyl)acetic acidN-methoxy-N-methyl-2-(2 3 6-trifluorophenyl)acetamideMethylmagnesium chloride1-(2 3 6-trifluorophenyl)propan-2-oneisopropyl N-(tert-butoxycarbonyl)-O-(methylsulfonyl)serinateisopropyl (tert-butoxycarbonyl)serinateisopropyl 2-((tert-butoxycarbonyl)amino)-5-oxo-4-(2 3 6-trifluorophenyl)hexanoatetert-butyl ((5S 6R)-6-methyl-2-oxo-5-(2 3 6-trifluorophenyl)piperidin-3-yl)carbamatetert-butyl ((3S 5S 6R)-6-methyl-2-oxo-5-(2 3 6-trifluorophenyl)piperidin-3-yl)carbamate2,2,2-trifluoroethyl trifluoromethanesulfonatetert-butyl ((5S 6R)-6-methyl-2-oxo-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-3-yl)carbamate(3S 5S 6R)-3-amino-6-methyl-1-(2 2 2-trifluoroethyl)-5-(2 3 6-trifluorophenyl)piperidin-2-one(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid1 2 4-trifluorobenzenebiacetyl3-hydroxy-3-(2 3 6-trifluorophenyl)butan-2-one3-(2 3 6-trifluorophenyl)but-3-en-2-one1-(2 3 6-trifluorophenyl)propan-2-oneisopropyl 2-((diphenylmethylene)amino)acetateisopropyl 2-((diphenylmethylene)amino)-5-oxo-4-(2 3 6-trifluorophenyl)hexanoateisopropyl 2-amino-5-oxo-4-(2 3 6-trifluorophenyl)hexanoateisopropyl (tert-butoxycarbonyl)glycinateisopropyl 2-((tert-butoxycarbonyl)amino)-5-oxo-4-(2 3 6-trifluorophenyl)hexanoate2,3-pyridinedicarboxylic acid; Quinolinic Aciddimethyl pyridine-2,3-dicarboxylatediMethyl 5-broMopyridine-2,3-dicarboxylate(5-bromopyridine-2,3-diyl)dimethanol hydrochloride(5-bromopyridine-2,3-diyl)bis(methylene) dimethanesulfonate1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one3-bromo-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-onemethyl 2'-oxo-1'-((2-(trimethylsilyl)ethoxy)methyl)-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylatemethyl (S)-2'-oxo-1'-((2-(trimethylsilyl)ethoxy)methyl)-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid2,3-dibromo-5-chloropyridineDimethylformamide2-bromo-5-chloronicotinaldehyde(2-bromo-5-chloropyridin-3-yl)methanol2-bromo-5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridine5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)picolinaldehydemethyl 1-tert-butyl-2-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-3-carboxylate(E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate(E)-1-(tert-butyl)-3-((5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one(E)-1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one(E)-1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one(S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one(S)-1'-(tert-butyl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carbaldehyde(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid(1S)-(6-methoxyquinolin-4-yl)((2R 4S 5R)-5-vinylquinuclidin-2-yl)methanol1-bromo-2-(bromomethyl)-4-methoxybenzene(2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methoxyquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide(2-bromo-5-chloropyridin-3-yl)methanol2-bromo-5-chloro-3-(((triisopropylsilyl)oxy)methyl)pyridinemethyl 5-chloro-3-(((triisopropylsilyl)oxy)methyl)picolinate(5-chloro-3-(((triisopropylsilyl)oxy)methyl)pyridin-2-yl)methanol5-chloro-2-(chloromethyl)-3-(((triisopropylsilyl)oxy)methyl)pyridinemethyl 1-(tert-butyl)-3-((5-chloro-3-(((triisopropylsilyl)oxy)methyl)pyridin-2-yl)methyl)-2-oxo-2 3-dihydro-1H-pyrrolo[2 3-b]pyridine-3-carboxylatemethyl 1-tert-butyl-2-oxo-1H,2H,3H-pyrrolo[2,3-b]pyridine-3-carboxylate1-(tert-butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-oneN-(tert-butyl)-3-methylpyridin-2-aminemethyl tert-butyl(3-methylpyridin-2-yl)carbamate1-(tert-butyl)-3-((5-chloro-3-(((triisopropylsilyl)oxy)methyl)pyridin-2-yl)methyl)-1 3-dihydro-2H-pyrrolo[2 3-b]pyridin-2-one(E)-1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one1'-((2-(trimethylsilyl)ethoxy)methyl)spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridine]-2',3(1'H)-dione3-nitro-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one(S)-3-iodo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid1H-pyrrolo[2,3-b]pyridine3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one1,4-dibromobutan-2-one1-methyl-3,5-dinitropyridin-2(1H)-one3-amino-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one(S)-3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-onemethyl (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate
